Activity
Hydrochlorothiazide belongs to the thiazide class of diuretics, acting on the kidney to reduce sodium (Na) reabsorption in the distal convoluted tubule. This reduces a osmotic pressure in the kidney, causing less water supply to exist as reabsorbed per collecting ducts.

Indications
These are typically wont to handle hypertension, congestive heart failure and symptomatic edema. These are effectual inside diabetes insipidus and is also periodically utilized within hypercalciuria.

Hypokalemia, an occasional side-effect, may be commonly prevented by potassium supplements or combining hydrodiuril by owning the potassium-sparing diuretic.

Side effects
hypokalemia hypomagnesemia hyperuricemia and gout hyperglycemia hypercholesterolemia